Star200+

Skill audit report

analytical-method-validation Audit report.

Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.

EXPERIMENTAL · REVIEWNeeds reviewGenerated Aug 22, 2026Heuristic metadata audit
85
Audit
75
Trust
92
Quality
77
Security
100
Maintain
92
Install

OpenAgentSkill Trust Score

75
Strong shortlist

OpenAgentSkill Trust Score

The Trust Score helps an agent decide whether a skill is safe enough to shortlist before installation.

GitHub adoption

PASS

100

34K GitHub stars

Stars/forks activity

PASS

97

34K stars, 3.3K forks; issue activity unavailable in current metadata

Recent maintenance

PASS

100

2d since push

License clarity

PASS

86

MIT

README/SKILL.md completeness

PASS

86

Metadata includes enough usage and workflow context

Dependency/runtime risk

INFO

72

command execution surface

Install availability

PASS

92

npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation

Install command safety

PASS

92

standard package or runtime install path

Permission surface

WARN

48

shell or command execution, filesystem or document access

Repository evidence

PASS

86

https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation

Review status

INFO

66

AI review data available

Agent Proven outcomes

INFO

54

No agent outcome data yet

Checks

Install and adoption review

8 Passed · 13 Needs review

Install path

92

PASS

npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation

Repository

88

PASS

https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation

License

86

PASS

MIT

Maintenance

100

PASS

2d since push

AI review

55

CHECK

SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.

README/SKILL.md completeness

86

PASS

Usable description available

Dependency risk

72

CHECK

command execution surface

Install command safety

92

PASS

standard package or runtime install path

Permission surface

48

FIX

shell or command execution, filesystem or document access

Stars/forks activity

97

PASS

34K stars, 3.3K forks; issue activity unavailable in current metadata

Adoption

88

PASS

34K GitHub stars

Financial decision safety

58

CHECK

Research-only use: do not treat output as financial advice or execute a position without human approval.

Warnings

  • Permission surface may require sandboxing
  • Financial research output is not financial advice; require human review before any live investment decision
  • SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.
  • The skill depends on legally obtained copies of paywalled standards; this is correctly handled but requires human access to those documents for full implementation.
  • No explicit 'do not execute arbitrary shell commands' guardrail is stated in SKILL.md, though the skill description and scripts appear constrained to safe, standard-library-only operations.
  • Financial research output is not financial advice; require human review before any live investment decision.
  • Quality score needs review
  • Permission surface needs review: shell or command execution, filesystem or document access
  • Permission surface: shell or command execution, filesystem or document access

Method

This report combines public metadata, AI review output, repository freshness, install readiness, OpenAgentSkill events, quality scoring, trust checks, and the agent safety gate. It is not a full source-code security review.

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