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Generate N analysis scripts from a single methodology template × multiple exposure/outcome combinations. The "80-person team" pattern — same validated method, swap variables only. Produces batch R/Python code + summary matrix.
Generate N analysis scripts from a single methodology template × multiple exposure/outcome combinations. The "80-person team" pattern — same validated method, swap variables only. Produces batch R/Python code + summary matrix.
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You are assisting a medical researcher in generating multiple analysis scripts from a single validated methodology template, each differing only in the exposure/outcome variable combination. This replicates the "80-person research team" pattern: one PI designs the methodology, and many researchers execute the same approach with different variable swaps.
nhis_cohort, cross_national, survey_weightedexposures: [depression, obesity, smoking]; outcomes: [diabetes, hypertension, CVD]exposure, outcome, (optional) subgroup_vars"all" keyword: generates all pairwise combinations from the listscode_only (just scripts) | execute (run + collect results) | full (code + results + summary)EXPOSURE_VAR: raw variable name in the databaseEXPOSURE_LABEL: human-readable label for tables/figuresEXPOSURE_CODING: how to derive binary/categorical exposureOUTCOME_VAR: raw variable nameOUTCOME_LABEL: human-readable labelOUTCOME_CODING: how to derive binary outcomeFor each exposure and outcome in the combination spec:
HE_glu >= 126 → diabetes = 1)smoking: current/former/never)| # | Exposure | Exposure Coding | Outcome | Outcome Coding | Covariates (adjusted) | Notes |
|---|----------|-----------------|---------|----------------|----------------------|-------|
| 1 | Depression (PHQ≥10) | BP_PHQ sum ≥10 | Diabetes | HE_glu≥126|HbA1c≥6.5|DE1_dg=1 | age,sex,edu,income,smoking,alcohol,obesity,CVD | — |
| 2 | Obesity (BMI≥25) | HE_obe ≥4 | Diabetes | same | age,sex,edu,income,smoking,alcohol,depression,CVD | obesity removed from covariates |
| ... | | | | | | |
For each combination in the matrix:
run_all.R or run_all.sh) that:
future/parallel)execute or full mode)Aggregate all results into a single summary:
Main Results Matrix (summary_matrix.csv):
| Exposure | Outcome | N | Events | Model 1 OR (95% CI) | Model 2 OR (95% CI) | Model 3 OR (95% CI) | p-value | Significant |
|---|---|---|---|---|---|---|---|---|
| Depression | Diabetes | 5,811 | 487 | 2.14 (1.52–3.01) | 1.89 (1.33–2.69) | 1.36 (0.91–2.05) | 0.137 | No |
| Obesity | Diabetes | 5,811 | 487 | 3.45 (2.71–4.39) | 3.38 (2.65–4.32) | 3.12 (2.42–4.02) | <0.001 | Yes |
| ... |
Subgroup Summary (subgroup_matrix.csv): Same format, stratified by subgroup variables.
Heatmap (optional): Visual matrix of effect sizes × significance, exposure on Y-axis, outcome on X-axis.
{working_dir}/batch_{timestamp}/
├── README.md — Batch run summary (N combinations, template used, date)
├── combination_matrix.csv — All exposure/outcome specs with coding
├── template/
│ └── base_template.R — The validated template (frozen copy)
├── scripts/
│ ├── 01_depression_diabetes.R
│ ├── 02_obesity_diabetes.R
│ ├── ...
│ └── run_all.R — Master execution script
├── results/
│ ├── 01_depression_diabetes/
│ │ ├── table1.csv
│ │ ├── main_results.csv
│ │ └── subgroup_results.csv
│ ├── 02_obesity_diabetes/
│ │ └── ...
│ └── ...
├── summary/
│ ├── summary_matrix.csv — Main results across all combinations
│ ├── subgroup_matrix.csv — Subgroup results across all combinations
│ ├── failed_runs.csv — Combinations that failed + error messages
│ └── heatmap.png — Optional effect size × significance visual
└── logs/
└── batch_execution.log — Timing + error log
/analyze-stats code-quality gate (check_generated_code.py --code-dir {batch_dir} --strict) and clear every Major (MISSING_SEED, HARDCODED_DATA_LITERAL, HARDCODED_ABS_PATH, INPLACE_SOURCE_OVERWRITE) before batch execution.When cross_national: true:
| Need | Skill |
|---|---|
| Variable coding lookup | analyze-stats survey_weighted guide |
| Template creation from paper | /replicate-study Phase 1–3 |
| Cross-national paired analysis | /cross-national |
| ICD-10 claims algorithms | analyze-stats nhis_icd10_mapping guide |
| Write manuscript from results | /write-paper (nhis_cohort or cross_national type) |
| Figure generation | /make-figures (forest plot of all combinations) |
/batch-cohort
DB: /path/to/knhanes/HN18.csv
Template: /path/to/validated_analysis.R
Exposures: [depression, obesity, smoking, heavy_drinking, low_income, low_education]
Outcome: diabetes
Mode: full
/batch-cohort
DB Korea: /path/to/knhanes/HN18.csv
DB US: /path/to/nhanes/
Template: cross_national
Exposures: [depression, obesity, smoking]
Outcomes: [diabetes, hypertension, metabolic_syndrome]
cross_national: true
Mode: execute
/batch-cohort
DB: /path/to/nhis_sample_cohort.csv
Template: nhis_cohort
Exposures: [atrial_fibrillation, heart_failure, COPD, CKD]
Outcomes: [all_cause_mortality, cardiovascular_death, stroke]
Mode: code_only
[VERIFY: variable_name] and ask the user to confirm against the data dictionary./search-lit for all citations.name: batch-cohort description: Generate N analysis scripts from a single methodology template × multiple exposure/outcome combinations. The "80-person team" pattern — same validated method, swap variables only. Produces batch R/Python code + summary matrix. triggers: batch cohort, batch analysis, 대량 분석, 변수 교체, variable swap, mass production, 80명 팀, batch generate, 일괄 코드 생성, exposure outcome matrix, combinatorial analysis tools: Read, Write, Edit, Bash, Grep, Glob model: opus
---
name: batch-cohort
description: Generate N analysis scripts from a single methodology template × multiple exposure/outcome combinations. The "80-person team" pattern — same validated method, swap variables only. Produces batch R/Python code + summary matrix.
triggers: batch cohort, batch analysis, 대량 분석, 변수 교체, variable swap, mass production, 80명 팀, batch generate, 일괄 코드 생성, exposure outcome matrix, combinatorial analysis
tools: Read, Write, Edit, Bash, Grep, Glob
model: opus
---
# Batch Cohort Analysis Skill
You are assisting a medical researcher in generating multiple analysis scripts from a single
validated methodology template, each differing only in the exposure/outcome variable combination.
This replicates the "80-person research team" pattern: one PI designs the methodology, and
many researchers execute the same approach with different variable swaps.
## When to Use
- Researcher has a **validated analysis template** (e.g., from /replicate-study or /cross-national)
- Wants to explore **multiple exposure → outcome combinations** on the same database
- Goal: systematic variable-swap code generation + batch execution + result matrix
## Inputs
1. **Database path(s)**: CSV/SAS data files (KNHANES, NHANES, NHIS, or any cleaned cohort)
2. **Methodology template**: One of:
- Path to a validated R/Python analysis script (from /replicate-study or /cross-national)
- A paper type template name: `nhis_cohort`, `cross_national`, `survey_weighted`
- A source paper to extract methodology from (falls back to /replicate-study Phase 1)
3. **Combination spec**: A list of exposure/outcome pairs, provided as:
- Inline list: `exposures: [depression, obesity, smoking]; outcomes: [diabetes, hypertension, CVD]`
- CSV file with columns: `exposure`, `outcome`, (optional) `subgroup_vars`
- `"all"` keyword: generates all pairwise combinations from the lists
### Optional Inputs
- **Covariate set**: Fixed covariate list for all analyses (default: use template's set)
- **Subgroup variables**: Variables to stratify by (default: sex, age group)
- **Output format**: `code_only` (just scripts) | `execute` (run + collect results) | `full` (code + results + summary)
- **Cross-national mode**: If TRUE, generates paired scripts for both countries per combination
## Workflow
### Phase 1: Template Validation
1. Read the methodology template (R script or paper type reference).
2. Identify the **slot variables** — parts that change per combination:
- `EXPOSURE_VAR`: raw variable name in the database
- `EXPOSURE_LABEL`: human-readable label for tables/figures
- `EXPOSURE_CODING`: how to derive binary/categorical exposure
- `OUTCOME_VAR`: raw variable name
- `OUTCOME_LABEL`: human-readable label
- `OUTCOME_CODING`: how to derive binary outcome
3. Verify the template runs successfully on at least one combination before batch generation.
4. Output: template summary with identified slots → user approval.
### Phase 2: Variable Specification
For each exposure and outcome in the combination spec:
1. **Look up** the variable in the database:
- KNHANES: check variable name exists in the CSV header
- NHANES: check which table contains the variable (use codebook.csv if available)
- NHIS: check claims code or variable name
2. **Define coding**:
- Binary: threshold or category mapping (e.g., `HE_glu >= 126 → diabetes = 1`)
- Categorical: level definitions (e.g., `smoking: current/former/never`)
3. **Check covariate overlap**: If the exposure IS one of the standard covariates, remove it from the adjustment set for that analysis (no self-adjustment).
4. Output: **combination matrix** with all variable specifications.
```
| # | Exposure | Exposure Coding | Outcome | Outcome Coding | Covariates (adjusted) | Notes |
|---|----------|-----------------|---------|----------------|----------------------|-------|
| 1 | Depression (PHQ≥10) | BP_PHQ sum ≥10 | Diabetes | HE_glu≥126|HbA1c≥6.5|DE1_dg=1 | age,sex,edu,income,smoking,alcohol,obesity,CVD | — |
| 2 | Obesity (BMI≥25) | HE_obe ≥4 | Diabetes | same | age,sex,edu,income,smoking,alcohol,depression,CVD | obesity removed from covariates |
| ... | | | | | | |
```
### Phase 3: Batch Code Generation
For each combination in the matrix:
1. **Clone** the template script.
2. **Replace** slot variables with the combination-specific values.
3. **Adjust covariates**: Remove exposure variable from covariate list if present.
4. **Set output paths**: Each combination gets its own results subdirectory.
5. **Generate a master runner script** (`run_all.R` or `run_all.sh`) that:
- Executes all N scripts sequentially (or in parallel via `future`/`parallel`)
- Captures errors per script without stopping the batch
- Logs execution time per analysis
### Phase 4: Batch Execution (if `execute` or `full` mode)
1. Run the master script.
2. Collect results from each combination's output directory.
3. Handle failures gracefully:
- Log which combinations failed and why
- Common failures: convergence issues, too few events, empty subgroups
- Suggest fixes for failed combinations
### Phase 5: Summary Matrix
Aggregate all results into a single summary:
**Main Results Matrix** (`summary_matrix.csv`):
| Exposure | Outcome | N | Events | Model 1 OR (95% CI) | Model 2 OR (95% CI) | Model 3 OR (95% CI) | p-value | Significant |
|----------|---------|---|--------|---------------------|---------------------|---------------------|---------|-------------|
| Depression | Diabetes | 5,811 | 487 | 2.14 (1.52–3.01) | 1.89 (1.33–2.69) | 1.36 (0.91–2.05) | 0.137 | No |
| Obesity | Diabetes | 5,811 | 487 | 3.45 (2.71–4.39) | 3.38 (2.65–4.32) | 3.12 (2.42–4.02) | <0.001 | Yes |
| ... | | | | | | | | |
**Subgroup Summary** (`subgroup_matrix.csv`): Same format, stratified by subgroup variables.
**Heatmap** (optional): Visual matrix of effect sizes × significance, exposure on Y-axis, outcome on X-axis.
## Output Files
```
{working_dir}/batch_{timestamp}/
├── README.md — Batch run summary (N combinations, template used, date)
├── combination_matrix.csv — All exposure/outcome specs with coding
├── template/
│ └── base_template.R — The validated template (frozen copy)
├── scripts/
│ ├── 01_depression_diabetes.R
│ ├── 02_obesity_diabetes.R
│ ├── ...
│ └── run_all.R — Master execution script
├── results/
│ ├── 01_depression_diabetes/
│ │ ├── table1.csv
│ │ ├── main_results.csv
│ │ └── subgroup_results.csv
│ ├── 02_obesity_diabetes/
│ │ └── ...
│ └── ...
├── summary/
│ ├── summary_matrix.csv — Main results across all combinations
│ ├── subgroup_matrix.csv — Subgroup results across all combinations
│ ├── failed_runs.csv — Combinations that failed + error messages
│ └── heatmap.png — Optional effect size × significance visual
└── logs/
└── batch_execution.log — Timing + error log
```
## Critical Rules
1. **Never modify the core methodology** across combinations — only swap exposure/outcome/covariates.
2. **Remove self-adjustment**: If exposure = BMI, remove obesity from covariates. If exposure = education/income, remove the same variable from covariates. If outcome = MetS, consider removing obesity from covariates. Document all removals.
3. **Weighted analysis mandatory** for KNHANES/NHANES/NHIS — inherited from template.
4. **Event count check**: Before running, verify each outcome has ≥10 events per covariate (EPV rule). Flag underpowered combinations.
5. **Multiple comparisons**: When generating >5 combinations, include a Bonferroni-corrected significance column in the summary matrix. Add a note about exploratory vs confirmatory framing.
6. **Reproducibility**: Freeze the template version. Include a SHA256 hash of the data file in README.
7. **No p-hacking framing**: The summary matrix is for **hypothesis generation**, not confirmation. State this explicitly in README and any manuscript output.
8. **Outcome definitions MUST include physician diagnosis**: Diabetes = FPG≥126 OR HbA1c≥6.5 OR physician-diagnosed (KNHANES: DE1_dg=1, NHANES: DIQ010="Yes"). Hypertension = SBP≥140 OR DBP≥90 OR physician-diagnosed (KNHANES: DI1_dg=1, NHANES: BPQ020="Yes"). Lab-only definitions systematically overestimate exposure→outcome associations (validated: Joo 2026 replication showed US depression→DM wOR 1.92 without vs 1.54 with physician dx).
9. **Full covariate set is default**: Always use 8 covariates (age, sex, education, income, smoking, alcohol, obesity, CVD) unless explicitly justified. Minimal models (age+sex+BMI only) overestimate effects due to residual confounding.
10. **Generated-code quality gate**: Because this skill emits N near-identical scripts, a single reproducibility slip (a missing seed, an absolute path, a hand-typed data literal) replicates across the whole batch. After Phase 3, lint the generated scripts with the `/analyze-stats` code-quality gate (`check_generated_code.py --code-dir {batch_dir} --strict`) and clear every Major (`MISSING_SEED`, `HARDCODED_DATA_LITERAL`, `HARDCODED_ABS_PATH`, `INPLACE_SOURCE_OVERWRITE`) before batch execution.
## Cross-National Batch Mode
When `cross_national: true`:
- Generate paired scripts for each combination (Korea + US)
- Summary matrix includes both countries side-by-side
- Direction agreement column: ✓ if both countries show same direction of effect
- Uses /cross-national skill's dual-survey-design approach
## Integration with Upstream Skills
| Need | Skill |
|------|-------|
| Variable coding lookup | `analyze-stats` survey_weighted guide |
| Template creation from paper | `/replicate-study` Phase 1–3 |
| Cross-national paired analysis | `/cross-national` |
| ICD-10 claims algorithms | `analyze-stats` nhis_icd10_mapping guide |
| Write manuscript from results | `/write-paper` (nhis_cohort or cross_national type) |
| Figure generation | `/make-figures` (forest plot of all combinations) |
## Example Invocations
### Basic: Single DB, Multiple Exposures × Single Outcome
```
/batch-cohort
DB: /path/to/knhanes/HN18.csv
Template: /path/to/validated_analysis.R
Exposures: [depression, obesity, smoking, heavy_drinking, low_income, low_education]
Outcome: diabetes
Mode: full
```
### Cross-National: Full Matrix
```
/batch-cohort
DB Korea: /path/to/knhanes/HN18.csv
DB US: /path/to/nhanes/
Template: cross_national
Exposures: [depression, obesity, smoking]
Outcomes: [diabetes, hypertension, metabolic_syndrome]
cross_national: true
Mode: execute
```
### NHIS Cohort: Claims-Based Batch
```
/batch-cohort
DB: /path/to/nhis_sample_cohort.csv
Template: nhis_cohort
Exposures: [atrial_fibrillation, heart_failure, COPD, CKD]
Outcomes: [all_cause_mortality, cardiovascular_death, stroke]
Mode: code_only
```
## Anti-Hallucination
- **Never fabricate variable names, dataset column names, or variable codings.** If a variable mapping is uncertain, output `[VERIFY: variable_name]` and ask the user to confirm against the data dictionary.
- **Never fabricate statistical results** — no invented p-values, effect sizes, confidence intervals, or sample sizes. All numbers must come from executed code output.
- **Never generate references from memory.** Use `/search-lit` for all citations.
- If a function, package, or API does not exist or you are unsure, say so explicitly rather than guessing.
Skill source recorded
Skill instructions are recorded. This is not a runtime test, safety guarantee or compatibility certification.
Review before install: Avoid automatic install
License: MIT
Listed tools are metadata hints, not tested compatibility. Agent prompts are suggested handoffs.
Repository metadata and review signals are advisory. Popularity, source discovery and successful execution are different facts.
Version reported in registry metadata; check source releases before relying on it.
Quality
72/100
Strong
Trust
67/100
This page exposes the same decision, trust, audit, use-case, and install signals through the Registry API, so agents can rank this skill without scraping the UI.
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"risk_label": "Risky",
"warnings": [
"Dependency or permission surface needs review",
"Permission surface may require sandboxing",
"Potential broker, wallet, exchange, or real-money execution surface; sandbox and explicit approval are required",
"This skill may touch real-money trading, broker, wallet, or exchange operations; use only in a sandbox with explicit approval.",
"Quality score needs review",
"Permission surface needs review: shell or command execution, filesystem or document access",
"Dependency/runtime risk: command execution surface, network or browser surface",
"Permission surface: shell or command execution, filesystem or document access"
]
},
"safety_gate": {
"tier": "blocked",
"label": "Blocked for auto-install",
"auto_install_policy": "block",
"auto_install_allowed": false,
"human_review_required": true,
"blocked": true,
"recommended_action": "Do not auto-install. Inspect the source, dependencies, and permission surface first."
},
"quality": {
"score": 72,
"label": "Strong"
},
"supply": {
"track": "Coding and developer agents",
"scenario": "Coding agents",
"maintenance": "17d since push",
"risk": "Risky"
},
"alternative_skills": [],
"do_not_use_when": [
"teams that need a vendor-supported SLA",
"high-compliance environments without internal security review",
"No major risk signals from current metadata",
"Audit risk risky exceeds max_risk=medium",
"High-risk permission hints: Shell or command execution",
"Dependency or permission surface needs review",
"Permission surface may require sandboxing",
"Potential broker, wallet, exchange, or real-money execution surface; sandbox and explicit approval are required"
],
"agent_contract": {
"task_input": "Use batch-cohort in an agent workflow",
"recommended_action": "Do not auto-install. Inspect the source, dependencies, and permission surface first.",
"install_policy": "block",
"minimum_review_before_use": [
"Trust: 75/100 Strong shortlist",
"Audit: 80/100 Risky",
"Safety: 48/100 Avoid automatic install",
"Review repository, license, install command, and permission surface before production use."
],
"expected_agent_output": {
"selected_skill": "aperivue-batch-cohort (batch-cohort)",
"install_command": "npx skills add Aperivue/medsci-skills --skill batch-cohort",
"risk_summary": "Risky; Blocked for auto-install; Review before production",
"verification_result": "Report the smallest successful task, files touched, warnings, and any missing setup."
}
},
"outcome_feedback": {
"endpoint": "https://www.openagentskill.com/api/agent/outcome",
"method": "POST",
"requires_resolve_event_id": true,
"event_id_source": "Use install_receipt.outcome_feedback.event_id or feedback.event_id returned by /api/agent/resolve for the current task.",
"expected_outcomes": [
"success",
"failed",
"not_relevant",
"blocked_by_risk",
"setup_required"
],
"payload_template": {
"event_id": "<install_receipt.outcome_feedback.event_id or feedback.event_id from /api/agent/resolve>",
"skill_slug": "aperivue-batch-cohort",
"task": "Use batch-cohort in an agent workflow",
"agent": "codex",
"outcome": "success",
"install_used": true,
"risk_blocked": false,
"setup_required": false,
"task_success": true,
"output_quality": 4,
"error_type": null,
"human_review_required": false,
"workspace": "sandbox",
"time_to_useful_ms": 120000,
"notes": "Report the smallest successful task, setup friction, files touched, and risk notes."
}
},
"endpoints": {
"web": "https://www.openagentskill.com/skills/aperivue-batch-cohort",
"api": "https://www.openagentskill.com/api/agent/skills/aperivue-batch-cohort",
"audit": "https://www.openagentskill.com/skills/aperivue-batch-cohort/audit",
"eval": "https://www.openagentskill.com/api/agent/evals?slug=aperivue-batch-cohort&task=Use%20batch-cohort%20in%20an%20agent%20workflow&max_risk=medium",
"resolve": "https://www.openagentskill.com/api/agent/resolve?task=Use%20batch-cohort%20in%20an%20agent%20workflow&agent=codex&max_risk=medium",
"receipt": "https://www.openagentskill.com/api/agent/receipt?task=Use%20batch-cohort%20in%20an%20agent%20workflow&agent=codex&max_risk=medium&format=text",
"install": "https://www.openagentskill.com/api/skills/aperivue-batch-cohort/install",
"manifest": "https://www.openagentskill.com/api/registry/manifest/aperivue-batch-cohort"
}
}Listing source
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Audit
80/100
Risky
Copies are not installs. Installation counts require a reported successful installation; they are not a blanket quality guarantee.