Alternatives

Salmon alternatives for AI agents.

Compare similar skills by workflow fit, trust score, quality, GitHub adoption, maintenance, and install readiness.

Current skill

Salmon

🐟 🍣 🍱 Highly-accurate & wicked fast transcript-level quantification from RNA-seq reads using selective alignment

87
Quality
88
Trust
893
Stars
#1

Bowtie2

Similarity 117Trust 86Excellent 86

A fast and sensitive gapped read aligner

794 starsJun 1, 2026 pushgeo-scienceC++Bioinformatics
$ npx skills add BenLangmead/bowtie2
#2

PyDESeq2

Similarity 117Trust 86Excellent 86

A Python implementation of the DESeq2 pipeline for bulk RNA-seq DEA.

753 starsJun 15, 2026 pushgeo-sciencePythonBioinformatics
$ npx skills add scverse/PyDESeq2
#3

Biopython

Similarity 116Trust 91Excellent 100

Official git repository for Biopython (originally converted from CVS)

5.1K starsJun 8, 2026 pushgeo-sciencePythonBioinformatics
$ npx skills add biopython/biopython
#4

Nextflow

Similarity 115Trust 92Excellent 100

A DSL for data-driven computational pipelines

3.4K starsJun 16, 2026 pushgeo-scienceGroovyBioinformatics
$ npx skills add nextflow-io/nextflow
#5

Fastp

Similarity 115Trust 95Excellent 100

An ultra-fast all-in-one FASTQ preprocessor (QC/adapters/trimming/filtering/splitting/merging...)

2.4K starsJun 1, 2026 pushgeo-scienceC++Bioinformatics
$ npx skills add OpenGene/fastp
#6

ColabFold

Similarity 115Trust 93Excellent 100

Making Protein folding accessible to all!

2.8K starsJun 15, 2026 pushgeo-scienceJupyter NotebookBioinformatics
$ npx skills add sokrypton/ColabFold
#7

Scanpy

Similarity 115Trust 93Excellent 100

Single-cell analysis in Python. Scales to >100M cells.

2.5K starsJun 15, 2026 pushgeo-sciencePythonBioinformatics
$ npx skills add scverse/scanpy
#8

MMseqs2

Similarity 115Trust 93Excellent 100

MMseqs2: ultra fast and sensitive search and clustering suite

2.1K starsJun 15, 2026 pushgeo-scienceCBioinformatics
$ npx skills add soedinglab/MMseqs2
#9

Minimap2

Similarity 114Trust 89Excellent 100

A versatile pairwise aligner for genomic and spliced nucleotide sequences

2.2K starsMay 19, 2026 pushgeo-scienceCBioinformatics
$ npx skills add lh3/minimap2
#10

Scikit Bio

Similarity 114Trust 95Excellent 100

scikit-bio: a community-driven Python library for bioinformatics, providing versatile data structures, algorithms and educational resources.

1.2K starsJun 8, 2026 pushgeo-sciencePythonBioinformatics
$ npx skills add scikit-bio/scikit-bio
#11

Seqkit

Similarity 114Trust 92Excellent 100

A cross-platform and ultrafast toolkit for FASTA/Q file manipulation

1.6K starsJun 16, 2026 pushgeo-scienceGoBioinformatics
$ npx skills add shenwei356/seqkit
#12

Bioconda Recipes

Similarity 114Trust 89Excellent 100

Conda recipes for the bioconda channel.

1.8K starsJun 16, 2026 pushgeo-scienceShellBioinformatics
$ npx skills add bioconda/bioconda-recipes
#13

Gatk

Similarity 114Trust 89Excellent 99

Official code repository for GATK versions 4 and up

2.0K starsJun 16, 2026 pushgeo-scienceJavaBioinformatics
$ npx skills add broadinstitute/gatk
#14

Cromwell

Similarity 114Trust 94Excellent 100

Scientific workflow engine designed for simplicity & scalability. Trivially transition between one off use cases to massive scale production environments

1.1K starsJun 15, 2026 pushgeo-scienceScalaBioinformatics
$ npx skills add broadinstitute/cromwell
#15

Omicverse

Similarity 114Trust 94Excellent 100

A python library for multi omics included bulk, single cell and spatial RNA-seq analysis.

1.0K starsJun 14, 2026 pushgeo-sciencePythonBioinformatics
$ npx skills add omicverse/omicverse
#16

Galaxy

Similarity 114Trust 89Excellent 99

Data intensive science for everyone.

1.8K starsJun 16, 2026 pushgeo-sciencePythonBioinformatics
$ npx skills add galaxyproject/galaxy

How to choose

When should you switch?

Use an alternative when it has a clearer install path, higher trust score, fresher maintenance, or better platform fit for your current agent stack. Keep Salmon if it already passes your workflow test and repository review.

Next step

Compare top candidates side by side

Open the compare page, test the install commands in a sandbox, and check each repository before using a skill in production.