{"query":"analytical-method-validation","filters":{"category":null,"platform":null,"track":null,"safety":null,"include_blocked":false,"min_stars":0},"total":1,"skills":[{"rank":1,"match_type":"exact","match_score":99,"raw_match_score":867.7,"semantic_relevance":100,"slug":"k-dense-ai-analytical-method-validation","name":"analytical-method-validation","description":"Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works.","tagline":"Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, q","category":"research","tags":["agent-skill"],"author":{"name":"K-Dense-AI","verified":false,"url":"https://github.com/K-Dense-AI"},"attribution":{"status":"registry_indexed","statusLabel":"Registry indexed","shortLabel":"REGISTRY INDEXED","sourceLabel":"recursive skill source sync","sourceDetail":"K-Dense-AI/scientific-agent-skills","creatorName":"K-Dense-AI","creatorUrl":"https://github.com/K-Dense-AI","sourceUrl":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation","indexedBy":"OpenAgentSkill community index","claimUrl":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation#claim-this-skill","claimCta":"Claim this skill","trustNote":"This listing was indexed from public sources and is not marked official until a maintainer claim is approved.","publicNote":"Attribution links to the public repository or creator profile. Creators can claim the listing to update ownership signals."},"stats":{"stars":33974,"forks":3307,"verified_installs":0,"install_attempts":0,"successful_runs":0,"total_outcomes":0,"downloads":0,"rating":0,"review_count":0,"quality_score":54.97},"quality":{"score":92,"tier":"excellent","label":"Excellent","summary":"High-confidence pick with strong adoption and healthy maintenance signals.","signals":[{"label":"GitHub stars","value":"34K","tone":"positive"},{"label":"Freshness","value":"2d ago","tone":"positive"},{"label":"Install ready","value":"Yes","tone":"positive"},{"label":"License","value":"MIT","tone":"neutral"}],"warnings":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation."]},"trust":{"version":"trust-score-v4","score":75,"tier":"strong","label":"Strong shortlist","summary":"Good trust signals with a few areas worth checking before rollout.","recommendedAction":"Test in a sandbox workflow and compare its install path with close alternatives.","dimensions":[{"id":"github_adoption","label":"GitHub adoption","score":100,"weight":0.13,"status":"pass","detail":"34K GitHub stars"},{"id":"repo_activity","label":"Stars/forks activity","score":97,"weight":0.08,"status":"pass","detail":"34K stars, 3.3K forks; issue activity unavailable in current metadata"},{"id":"maintenance","label":"Recent maintenance","score":100,"weight":0.14,"status":"pass","detail":"2d since push"},{"id":"license","label":"License clarity","score":86,"weight":0.09,"status":"pass","detail":"MIT"},{"id":"documentation","label":"README/SKILL.md completeness","score":52,"weight":0.14,"status":"warn","detail":"Public metadata needs stronger README/SKILL.md context"},{"id":"dependency_risk","label":"Dependency/runtime risk","score":90,"weight":0.12,"status":"pass","detail":"no major dependency risk hints in public metadata"},{"id":"installability","label":"Install availability","score":92,"weight":0.1,"status":"pass","detail":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation"},{"id":"install_safety","label":"Install command safety","score":92,"weight":0.1,"status":"pass","detail":"standard package or runtime install path"},{"id":"permission_surface","label":"Permission surface","score":86,"weight":0.07,"status":"pass","detail":"filesystem or document access"},{"id":"repository","label":"Repository evidence","score":86,"weight":0.04,"status":"pass","detail":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation"},{"id":"review_status","label":"Review status","score":66,"weight":0.05,"status":"info","detail":"AI review data available"},{"id":"agent_outcomes","label":"Agent Proven outcomes","score":54,"weight":0.13,"status":"info","detail":"No agent outcome data yet"}],"checks":[{"status":"pass","label":"GitHub adoption","detail":"34K GitHub stars"},{"status":"pass","label":"Stars/forks activity","detail":"34K stars, 3.3K forks; issue activity unavailable in current metadata"},{"status":"pass","label":"Recent maintenance","detail":"2d since push"},{"status":"pass","label":"License clarity","detail":"MIT"},{"status":"warn","label":"README/SKILL.md completeness","detail":"Public metadata needs stronger README/SKILL.md context"},{"status":"pass","label":"Dependency/runtime risk","detail":"no major dependency risk hints in public metadata"},{"status":"pass","label":"Install availability","detail":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation"},{"status":"pass","label":"Install command safety","detail":"standard package or runtime install path"},{"status":"pass","label":"Permission surface","detail":"filesystem or document access"},{"status":"pass","label":"Repository evidence","detail":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation"},{"status":"info","label":"Review status","detail":"AI review data available"},{"status":"info","label":"Agent Proven outcomes","detail":"No agent outcome data yet"},{"status":"warn","label":"Ownership","detail":"No approved owner claim yet"},{"status":"info","label":"OpenAgentSkill usage","detail":"No local usage activity yet"},{"status":"info","label":"Agent outcomes","detail":"No agent outcome data yet"}],"strengths":["AI review approved","Install path is available","Repository evidence is available","Recently maintained repository","Large GitHub adoption signal","Install command has no obvious high-risk pattern"],"warnings":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"],"evidence":{"stars":"34K GitHub stars","repoActivity":"34K stars, 3.3K forks","lastPushed":"2d since push","license":"MIT","repository":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation","install":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","installSafety":"standard package or runtime install path","permissionSurface":"filesystem or document access","documentation":"Thin public metadata","agentOutcomes":"No agent outcome data yet"},"installReadiness":{"ready":true,"command":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","policy":"human_review_before_install","label":"Human review before install","notes":["Install path is available","Repository evidence is available","License is declared","No Agent Proven outcome evidence yet","2d since push"]},"agentCompatibility":["Codex","Claude Code","Cursor","OpenAgentSkill CLI"],"riskSummary":{"level":"medium","label":"Review before production","notes":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"outcomeEvidence":{"total":0,"successes":0,"failures":0,"notRelevant":0,"successRate":null,"installAttempts":0,"riskBlocked":0,"setupRequired":0,"installSuccessRate":null,"avgOutputQuality":null,"avgTimeToUsefulMs":null,"productionOutcomes":0,"humanReviewRequired":0,"recentSuccessRate":null,"recentFailureRate":null,"uniqueAgents":0,"agentProvenScore":0,"agentProvenLabel":"Needs first agent run","lastOutcomeAt":null,"label":"No agent outcome data yet"},"autoInstall":{"allowed":false,"sandboxRequired":true,"policy":"human_review_before_install","reason":"Human review or sandbox validation is required before automatic installation."},"bestFor":["research","agent-skill"],"doNotUseFor":["Production credentials, payments, or irreversible account changes without explicit human review","Sensitive private data before reviewing repository code, license, and permission surface","Automatic installation in a production workspace"],"knownRisks":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"safety":{"score":71,"level":"review_before_install","label":"Review before install","safety_tier":{"tier":"reviewed","label":"Reviewed with permission notes","badge":"REVIEWED","summary":"Usable candidate, but the agent should surface permission and audit notes before installation.","recommended_action":"Require human approval before installing into a real workspace.","auto_install_policy":"review","reasons":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","71/100 agent safety score"]},"auto_install_allowed":false,"human_review_required":true,"blocked":false,"audit_risk":"needs_review","permission_hints":[{"id":"network","label":"Network access","reason":"Skill likely fetches remote pages, APIs, repositories, or external services.","severity":"medium"},{"id":"filesystem","label":"Filesystem access","reason":"Skill may read or write project files, documents, generated artifacts, or local workspace state.","severity":"medium"}],"policy_warnings":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation."],"constraints_applied":{"max_risk":"medium","needs_install_command":true,"min_stars":0}},"safety_gate":{"tier":"reviewed","label":"Reviewed with permission notes","badge":"REVIEWED","auto_install_policy":"review","auto_install_allowed":false,"human_review_required":true,"blocked":false,"recommended_action":"Require human approval before installing into a real workspace.","reasons":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","71/100 agent safety score"]},"supply_profile":{"track":{"slug":"research","label":"Research and knowledge work","shortLabel":"Research","description":"Deep research, source comparison, literature review, RAG, knowledge search, and reports."},"scenario":{"label":"Research agents","description":"I need my agent to research a topic, compare sources, and produce a concise report.","useCases":[{"slug":"research-agents","title":"Research agents"},{"slug":"testing-qa","title":"Testing and QA"},{"slug":"rag-knowledge","title":"RAG and knowledge"}]},"applicableAgents":["Claude Code","CLI","Codex","Cursor"],"install":{"ready":true,"command":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","primaryTarget":"CLI","targetCount":4},"githubQuality":{"stars":33974,"starsLabel":"34K","forks":3307,"license":"MIT","qualityScore":92,"trustScore":75,"auditScore":87},"maintenance":{"status":"fresh","label":"2d since push","daysSincePush":2,"lastPushedAt":"2026-08-20T13:03:17+00:00"},"risk":{"level":"needs_review","label":"Needs review","requiresReview":true,"notes":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","The skill depends on legally obtained copies of paywalled standards; this is correctly handled but requires human access to those documents for full implementation.","No explicit 'do not execute arbitrary shell commands' guardrail is stated in SKILL.md, though the skill description and scripts appear constrained to safe, standard-library-only operations.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"coverageTags":["Research","Research agents","agent-skill"]},"audit":{"audit_score":87,"risk_level":"needs_review","risk_label":"Needs review","warnings":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","The skill depends on legally obtained copies of paywalled standards; this is correctly handled but requires human access to those documents for full implementation.","No explicit 'do not execute arbitrary shell commands' guardrail is stated in SKILL.md, though the skill description and scripts appear constrained to safe, standard-library-only operations.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"decision":{"readiness_score":100,"readiness_label":"Production-ready","headline":"Primary pick for Research agents","role":"Primary pick","primary_fit":"Research agents","best_for":["Research agents workflows","Claude Code teams","teams that value GitHub adoption signals"],"risks":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","No OpenAgentSkill engagement data yet"],"next_steps":["Install it in a sandbox agent and run one Research agents task end to end.","Compare output quality, latency, and failure behavior against at least one alternative.","Promote it into production only after reviewing repository permissions, license, and maintenance signals."]},"agent_readable_metadata":{"version":"openagentskill-agent-metadata-v2","skill":{"slug":"k-dense-ai-analytical-method-validation","name":"analytical-method-validation","description":"Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works.","category":"research","url":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation","repository":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation","github_repo":"K-Dense-AI/scientific-agent-skills"},"suited_tasks":["Research agents workflows","Claude Code teams","teams that value GitHub adoption signals","Search sources","Extract claims","Synthesize findings","Run test suites","Capture failures"],"suited_agents":["Codex","Claude Code","Cursor","OpenAgentSkill CLI","CLI"],"install":{"command":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","ready":true,"targets":[{"id":"openagentskill-cli","label":"CLI","kind":"command","value":"npx --yes https://github.com/Leon-Drq/openagentskill/releases/download/cli-v0.2.1/openagentskill-0.2.1.tgz install k-dense-ai-analytical-method-validation"},{"id":"codex","label":"Codex","kind":"agent-prompt","value":"Install the \"analytical-method-validation\" agent skill from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation. Read its SKILL.md or equivalent instructions first, install only the files needed for this workspace, and summarize any required setup before using it. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"codex\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes."},{"id":"claude-code","label":"Claude Code","kind":"agent-prompt","value":"Add \"analytical-method-validation\" as a Claude Code skill from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation. Inspect the skill instructions, place the reusable skill files in the appropriate local skills location for this project, and report the activation steps. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"claude-code\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes."},{"id":"cursor","label":"Cursor","kind":"agent-prompt","value":"Turn \"analytical-method-validation\" from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation into a reusable Cursor project rule or agent instruction. Preserve the core workflow, adapt paths to this repo, and keep the rule scoped to tasks where it is relevant. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"cursor\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes."}],"handoff_url":"https://www.openagentskill.com/api/skills/k-dense-ai-analytical-method-validation/install","manifest_url":"https://www.openagentskill.com/api/registry/manifest/k-dense-ai-analytical-method-validation"},"trust":{"score":75,"label":"Strong shortlist","version":"trust-score-v4","install_policy":"human_review_before_install","evidence":{"stars":"34K GitHub stars","repoActivity":"34K stars, 3.3K forks","lastPushed":"2d since push","license":"MIT","repository":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation","install":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","installSafety":"standard package or runtime install path","permissionSurface":"filesystem or document access","documentation":"Thin public metadata","agentOutcomes":"No agent outcome data yet"},"outcome_evidence":{"total":0,"successes":0,"failures":0,"not_relevant":0,"success_rate":null,"recent_success_rate":null,"recent_failure_rate":null,"install_attempts":0,"install_success_rate":null,"risk_blocked":0,"setup_required":0,"avg_output_quality":null,"production_outcomes":0,"last_outcome_at":null,"label":"No agent outcome data yet"},"auto_install":{"allowed":false,"sandbox_required":true,"reason":"Human review or sandbox validation is required before automatic installation."},"best_for":["research","agent-skill"],"known_risks":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"agent_proven":{"version":"agent-proven-v1","score":0,"tier":"unproven","label":"Needs first agent run","summary":"No agent outcome reports yet. Use Resolve, run one narrow sandbox task, then report the result.","metrics":{"totalOutcomes":0,"successfulOutcomes":0,"failedOutcomes":0,"installAttempts":0,"installSuccessRate":null,"successRate":null,"recentSuccessRate":null,"recentFailureRate":null,"riskBlocked":0,"setupRequired":0,"notRelevant":0,"avgOutputQuality":null,"avgTimeToUsefulMs":null,"productionOutcomes":0,"humanReviewRequired":0,"uniqueAgents":0,"lastOutcomeAt":null},"signals":[],"penalties":["No real agent outcome evidence yet"]},"audit":{"score":87,"risk_level":"needs_review","risk_label":"Needs review","warnings":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","The skill depends on legally obtained copies of paywalled standards; this is correctly handled but requires human access to those documents for full implementation.","No explicit 'do not execute arbitrary shell commands' guardrail is stated in SKILL.md, though the skill description and scripts appear constrained to safe, standard-library-only operations.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"safety_gate":{"tier":"reviewed","label":"Reviewed with permission notes","auto_install_policy":"review","auto_install_allowed":false,"human_review_required":true,"blocked":false,"recommended_action":"Require human approval before installing into a real workspace."},"quality":{"score":92,"label":"Excellent"},"supply":{"track":"Research and knowledge work","scenario":"Research agents","maintenance":"2d since push","risk":"Needs review"},"alternative_skills":[],"do_not_use_when":["teams that need a vendor-supported SLA","production agents without a repository review","SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","No OpenAgentSkill engagement data yet","The skill depends on legally obtained copies of paywalled standards; this is correctly handled but requires human access to those documents for full implementation.","No explicit 'do not execute arbitrary shell commands' guardrail is stated in SKILL.md, though the skill description and scripts appear constrained to safe, standard-library-only operations.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"],"agent_contract":{"task_input":"Use analytical-method-validation in an agent workflow","recommended_action":"Require human approval before installing into a real workspace.","install_policy":"review","minimum_review_before_use":["Trust: 75/100 Strong shortlist","Audit: 87/100 Needs review","Safety: 71/100 Review before install","Review repository, license, install command, and permission surface before production use."],"expected_agent_output":{"selected_skill":"k-dense-ai-analytical-method-validation (analytical-method-validation)","install_command":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","risk_summary":"Needs review; Reviewed with permission notes; Review before production","verification_result":"Report the smallest successful task, files touched, warnings, and any missing setup."}},"outcome_feedback":{"endpoint":"https://www.openagentskill.com/api/agent/outcome","method":"POST","requires_resolve_event_id":true,"event_id_source":"Use install_receipt.outcome_feedback.event_id or feedback.event_id returned by /api/agent/resolve for the current task.","expected_outcomes":["success","failed","not_relevant","blocked_by_risk","setup_required"],"payload_template":{"event_id":"<install_receipt.outcome_feedback.event_id or feedback.event_id from /api/agent/resolve>","skill_slug":"k-dense-ai-analytical-method-validation","task":"Use analytical-method-validation in an agent workflow","agent":"codex","outcome":"success","install_used":true,"risk_blocked":false,"setup_required":false,"task_success":true,"output_quality":4,"error_type":null,"human_review_required":false,"workspace":"sandbox","time_to_useful_ms":120000,"notes":"Report the smallest successful task, setup friction, files touched, and risk notes."}},"endpoints":{"web":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation","api":"https://www.openagentskill.com/api/agent/skills/k-dense-ai-analytical-method-validation","audit":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation/audit","eval":"https://www.openagentskill.com/api/agent/evals?slug=k-dense-ai-analytical-method-validation&task=Use%20analytical-method-validation%20in%20an%20agent%20workflow&max_risk=medium","resolve":"https://www.openagentskill.com/api/agent/resolve?task=Use%20analytical-method-validation%20in%20an%20agent%20workflow&agent=codex&max_risk=medium","receipt":"https://www.openagentskill.com/api/agent/receipt?task=Use%20analytical-method-validation%20in%20an%20agent%20workflow&agent=codex&max_risk=medium&format=text","install":"https://www.openagentskill.com/api/skills/k-dense-ai-analytical-method-validation/install","manifest":"https://www.openagentskill.com/api/registry/manifest/k-dense-ai-analytical-method-validation"}},"machine_metadata":{"version":"openagentskill-agent-metadata-v2","skill":{"slug":"k-dense-ai-analytical-method-validation","name":"analytical-method-validation","description":"Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works.","category":"research","url":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation","repository":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation","github_repo":"K-Dense-AI/scientific-agent-skills"},"suited_tasks":["Research agents workflows","Claude Code teams","teams that value GitHub adoption signals","Search sources","Extract claims","Synthesize findings","Run test suites","Capture failures"],"suited_agents":["Codex","Claude Code","Cursor","OpenAgentSkill CLI","CLI"],"install":{"command":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","ready":true,"targets":[{"id":"openagentskill-cli","label":"CLI","kind":"command","value":"npx --yes https://github.com/Leon-Drq/openagentskill/releases/download/cli-v0.2.1/openagentskill-0.2.1.tgz install k-dense-ai-analytical-method-validation"},{"id":"codex","label":"Codex","kind":"agent-prompt","value":"Install the \"analytical-method-validation\" agent skill from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation. Read its SKILL.md or equivalent instructions first, install only the files needed for this workspace, and summarize any required setup before using it. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"codex\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes."},{"id":"claude-code","label":"Claude Code","kind":"agent-prompt","value":"Add \"analytical-method-validation\" as a Claude Code skill from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation. Inspect the skill instructions, place the reusable skill files in the appropriate local skills location for this project, and report the activation steps. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"claude-code\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes."},{"id":"cursor","label":"Cursor","kind":"agent-prompt","value":"Turn \"analytical-method-validation\" from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation into a reusable Cursor project rule or agent instruction. Preserve the core workflow, adapt paths to this repo, and keep the rule scoped to tasks where it is relevant. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"cursor\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes."}],"handoff_url":"https://www.openagentskill.com/api/skills/k-dense-ai-analytical-method-validation/install","manifest_url":"https://www.openagentskill.com/api/registry/manifest/k-dense-ai-analytical-method-validation"},"trust":{"score":75,"label":"Strong shortlist","version":"trust-score-v4","install_policy":"human_review_before_install","evidence":{"stars":"34K GitHub stars","repoActivity":"34K stars, 3.3K forks","lastPushed":"2d since push","license":"MIT","repository":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation","install":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","installSafety":"standard package or runtime install path","permissionSurface":"filesystem or document access","documentation":"Thin public metadata","agentOutcomes":"No agent outcome data yet"},"outcome_evidence":{"total":0,"successes":0,"failures":0,"not_relevant":0,"success_rate":null,"recent_success_rate":null,"recent_failure_rate":null,"install_attempts":0,"install_success_rate":null,"risk_blocked":0,"setup_required":0,"avg_output_quality":null,"production_outcomes":0,"last_outcome_at":null,"label":"No agent outcome data yet"},"auto_install":{"allowed":false,"sandbox_required":true,"reason":"Human review or sandbox validation is required before automatic installation."},"best_for":["research","agent-skill"],"known_risks":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"agent_proven":{"version":"agent-proven-v1","score":0,"tier":"unproven","label":"Needs first agent run","summary":"No agent outcome reports yet. Use Resolve, run one narrow sandbox task, then report the result.","metrics":{"totalOutcomes":0,"successfulOutcomes":0,"failedOutcomes":0,"installAttempts":0,"installSuccessRate":null,"successRate":null,"recentSuccessRate":null,"recentFailureRate":null,"riskBlocked":0,"setupRequired":0,"notRelevant":0,"avgOutputQuality":null,"avgTimeToUsefulMs":null,"productionOutcomes":0,"humanReviewRequired":0,"uniqueAgents":0,"lastOutcomeAt":null},"signals":[],"penalties":["No real agent outcome evidence yet"]},"audit":{"score":87,"risk_level":"needs_review","risk_label":"Needs review","warnings":["SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","The skill depends on legally obtained copies of paywalled standards; this is correctly handled but requires human access to those documents for full implementation.","No explicit 'do not execute arbitrary shell commands' guardrail is stated in SKILL.md, though the skill description and scripts appear constrained to safe, standard-library-only operations.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"]},"safety_gate":{"tier":"reviewed","label":"Reviewed with permission notes","auto_install_policy":"review","auto_install_allowed":false,"human_review_required":true,"blocked":false,"recommended_action":"Require human approval before installing into a real workspace."},"quality":{"score":92,"label":"Excellent"},"supply":{"track":"Research and knowledge work","scenario":"Research agents","maintenance":"2d since push","risk":"Needs review"},"alternative_skills":[],"do_not_use_when":["teams that need a vendor-supported SLA","production agents without a repository review","SKILL.md excerpt does not include the full script usage and command outcomes; the agent may not know expected outputs or error handling without additional documentation.","No OpenAgentSkill engagement data yet","The skill depends on legally obtained copies of paywalled standards; this is correctly handled but requires human access to those documents for full implementation.","No explicit 'do not execute arbitrary shell commands' guardrail is stated in SKILL.md, though the skill description and scripts appear constrained to safe, standard-library-only operations.","Quality score needs review","README/SKILL.md completeness: Public metadata needs stronger README/SKILL.md context"],"agent_contract":{"task_input":"Use analytical-method-validation in an agent workflow","recommended_action":"Require human approval before installing into a real workspace.","install_policy":"review","minimum_review_before_use":["Trust: 75/100 Strong shortlist","Audit: 87/100 Needs review","Safety: 71/100 Review before install","Review repository, license, install command, and permission surface before production use."],"expected_agent_output":{"selected_skill":"k-dense-ai-analytical-method-validation (analytical-method-validation)","install_command":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","risk_summary":"Needs review; Reviewed with permission notes; Review before production","verification_result":"Report the smallest successful task, files touched, warnings, and any missing setup."}},"outcome_feedback":{"endpoint":"https://www.openagentskill.com/api/agent/outcome","method":"POST","requires_resolve_event_id":true,"event_id_source":"Use install_receipt.outcome_feedback.event_id or feedback.event_id returned by /api/agent/resolve for the current task.","expected_outcomes":["success","failed","not_relevant","blocked_by_risk","setup_required"],"payload_template":{"event_id":"<install_receipt.outcome_feedback.event_id or feedback.event_id from /api/agent/resolve>","skill_slug":"k-dense-ai-analytical-method-validation","task":"Use analytical-method-validation in an agent workflow","agent":"codex","outcome":"success","install_used":true,"risk_blocked":false,"setup_required":false,"task_success":true,"output_quality":4,"error_type":null,"human_review_required":false,"workspace":"sandbox","time_to_useful_ms":120000,"notes":"Report the smallest successful task, setup friction, files touched, and risk notes."}},"endpoints":{"web":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation","api":"https://www.openagentskill.com/api/agent/skills/k-dense-ai-analytical-method-validation","audit":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation/audit","eval":"https://www.openagentskill.com/api/agent/evals?slug=k-dense-ai-analytical-method-validation&task=Use%20analytical-method-validation%20in%20an%20agent%20workflow&max_risk=medium","resolve":"https://www.openagentskill.com/api/agent/resolve?task=Use%20analytical-method-validation%20in%20an%20agent%20workflow&agent=codex&max_risk=medium","receipt":"https://www.openagentskill.com/api/agent/receipt?task=Use%20analytical-method-validation%20in%20an%20agent%20workflow&agent=codex&max_risk=medium&format=text","install":"https://www.openagentskill.com/api/skills/k-dense-ai-analytical-method-validation/install","manifest":"https://www.openagentskill.com/api/registry/manifest/k-dense-ai-analytical-method-validation"}},"platforms":["Claude Code"],"use_cases":[{"slug":"research-agents","title":"Research agents","url":"https://www.openagentskill.com/use-cases/research-agents"},{"slug":"testing-qa","title":"Testing and QA","url":"https://www.openagentskill.com/use-cases/testing-qa"},{"slug":"rag-knowledge","title":"RAG and knowledge","url":"https://www.openagentskill.com/use-cases/rag-knowledge"},{"slug":"browser-automation","title":"Browser automation","url":"https://www.openagentskill.com/use-cases/browser-automation"}],"install":"npx skills add K-Dense-AI/scientific-agent-skills --skill analytical-method-validation","install_targets":[{"id":"openagentskill-cli","label":"CLI","title":"OpenAgentSkill CLI","kind":"command","value":"npx --yes https://github.com/Leon-Drq/openagentskill/releases/download/cli-v0.2.1/openagentskill-0.2.1.tgz install k-dense-ai-analytical-method-validation","description":"Resolve policy, run the source installer safely, and report a verified install receipt.","copyLabel":"Copy command"},{"id":"codex","label":"Codex","title":"Codex install prompt","kind":"agent-prompt","value":"Install the \"analytical-method-validation\" agent skill from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation. Read its SKILL.md or equivalent instructions first, install only the files needed for this workspace, and summarize any required setup before using it. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"codex\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes.","description":"Give Codex a repo-aware install prompt when the skill is not available through a local CLI.","copyLabel":"Copy prompt"},{"id":"claude-code","label":"Claude Code","title":"Claude Code skill prompt","kind":"agent-prompt","value":"Add \"analytical-method-validation\" as a Claude Code skill from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation. Inspect the skill instructions, place the reusable skill files in the appropriate local skills location for this project, and report the activation steps. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"claude-code\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes.","description":"Use this prompt to ask Claude Code to add the skill and explain the local activation steps.","copyLabel":"Copy prompt"},{"id":"cursor","label":"Cursor","title":"Cursor rule prompt","kind":"agent-prompt","value":"Turn \"analytical-method-validation\" from https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation into a reusable Cursor project rule or agent instruction. Preserve the core workflow, adapt paths to this repo, and keep the rule scoped to tasks where it is relevant. Skill purpose: Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include \"method validation\", \"analytical method validation\", \"AMV\", \"validation protocol\", \"acceptance criteria\", \"linearity\", \"reportable range\", \"accuracy and precision\", \"repeatability\", \"intermediate precision\", \"recovery\", \"LOD\", \"LOQ\", \"detection limit\", \"quantitation limit\", \"specificity\", \"robustness\", \"method transfer\", \"method comparison\", \"Deming\", \"Passing-Bablok\", \"Bland-Altman\", \"equivalence testing\", \"OOS investigation\", \"ICH Q2\", \"Q2(R2)\", \"Q14\", \"USP 1225\", \"ICH M10\", \"incurred sample reanalysis\", \"ISR\", \"CLSI EP\", and any request to show that an assay works. After the install attempt, report the result to https://www.openagentskill.com/api/agent/outcome with POST JSON {\"event_id\":\"install_<unique-id>\",\"skill_slug\":\"k-dense-ai-analytical-method-validation\",\"task\":\"Install analytical-method-validation\",\"agent\":\"cursor\",\"outcome\":\"success\",\"install_used\":true}. Replace event_id with a unique value and outcome with success or failed. Report success only after the skill is installed and a minimal verification passes.","description":"Use this when installing as Cursor project rules or reusable agent instructions.","copyLabel":"Copy prompt"}],"repository":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation","github_repo":"K-Dense-AI/scientific-agent-skills","version":"1.0.0","license":"MIT","updated_at":"2026-08-20T13:22:49.178433+00:00","canonical_key":"k-dense-ai/scientific-agent-skills#skills/analytical-method-validation","recommendation_reasons":["Matches task terms: analytical, method, validation","Strong GitHub adoption: 33,974 stars","Install handoff is available","Repository freshness signal is available","Registry match score 99"],"urls":{"web":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation","api":"https://www.openagentskill.com/api/agent/skills/k-dense-ai-analytical-method-validation","install_api":"https://www.openagentskill.com/api/skills/k-dense-ai-analytical-method-validation/install","audit":"https://www.openagentskill.com/skills/k-dense-ai-analytical-method-validation/audit","repository":"https://github.com/K-Dense-AI/scientific-agent-skills/tree/main/skills/analytical-method-validation"}}],"meta":{"endpoint":"/api/skills/search","canonical_agent_endpoint":"/api/agent/resolve","lookup_intent":true,"exact_match_found":true,"match_counts":{"exact":1,"near":0,"related":0},"no_match_message":null,"safety_policy":"Blocked candidates are excluded by default. Pass include_blocked=true only for manual audit workflows.","agent_friendly":true,"api_version":"1.0","generated_at":"2026-08-22T18:17:28.983Z"}}