OpenAgentSkill Registry Manifest
Skill: clinical-variant-prioritizer
Slug: clawbio-clinical-variant-prioritizer
Category: automation
Description: Screen a genotype set (array or WGS-derived) against OMIM-morbid, ACMG-SF and Hereditary-Cancer gene panels and prioritise carried variants by ClinVar significance, gnomAD frequency, inheritance model and zygosity, following the pathogenicity-screening method of Corpas et al. 2021 (Whole Genome Interpretation for a Family of Five).

Agent fit:
- Decision: 89/100 Production-ready
- Primary fit: Research agents
- Role: Primary pick

Supply profile:
- Track: Coding and developer agents
- Scenario: GitHub automation
- Applicable agents: Claude Code, CLI, Codex, Cursor
- Maintenance: 1d since push
- Risk: Needs review

Trust:
- Trust score: 73/100 Strong shortlist
- Audit: 81/100 Needs review

Attribution:
- Status: Registry indexed
- Source: github candidate review
- Creator: ClawBio
- Claim URL: https://www.openagentskill.com/skills/clawbio-clinical-variant-prioritizer#claim-this-skill

Install:
npx skills add ClawBio/ClawBio --skill clinical-variant-prioritizer

URLs:
- Web: https://www.openagentskill.com/skills/clawbio-clinical-variant-prioritizer
- API: https://www.openagentskill.com/api/agent/skills/clawbio-clinical-variant-prioritizer
- Install API: https://www.openagentskill.com/api/skills/clawbio-clinical-variant-prioritizer/install
- Repository: https://github.com/ClawBio/ClawBio/tree/main/skills/clinical-variant-prioritizer